Directed ortho Metalation (DoM)-Linked Corriu-Kumada, Negishi, and Suzuki-Miyaura Cross-Coupling Protocols: A Comparative Study was written by Quesnelle, Claude A.;Snieckus, Victor. And the article was included in Synthesis in 2018.Application In Synthesis of N,N-Diethylsalicylamide This article mentions the following:
A systematic study of the widely used, titled transition-metal-catalyzed cross-coupling reactions with attention to context with the directed orthometalation (DoM) was reported. In general, the Suzuki-Miyaura and Negishi protocols showed greater scope and better yields than the Corriu-Kumada variant, although the latter qual. proceeded at fastest rate but had low functional group tolerance. The Negishi process was shown to be useful for substrates with nucleophile and base-sensitive functionality and it was comparable to the Suzuki-Miyaura reaction in efficiency. The link of these cross-coupling reactions to the DoM strategy lends itself to the regioselective construction of diversely substituted aromatics and heteroaromatics In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Application In Synthesis of N,N-Diethylsalicylamide).
N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Application In Synthesis of N,N-Diethylsalicylamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics