Synthesis and pharmacological and conformational studies of 4-benzylisoquinolines, papaverine analogs was written by Bouvier, Philippe;Branceni, Dan;Prouteau, Monique;Prudhommeaux, Elie;Viel, Claude. And the article was included in European Journal of Medicinal Chemistry in 1976.SDS of cas: 61189-99-9 This article mentions the following:
Benzylisoquinolines I (R = Ph, 4-ClC6H4, 2-FC6H4, 3-FC6H4, 4-FC6H4, 2-ClC6H4, 2,6-Cl2C6H3, 3,4-Cl2C6H3, 4-MeOC6H4, 3,4-(MeO)2C6H3, 3,4,5-(MeO)3C6H2, 3,4-(methylenedioxy)phenyl, 4-HCOC6H4, 4-Me2NC6H4, 4-O2NC6H4; R1 = 6-OMe, R2 = 7-OMe, R3 = H; R1 = 7-OMe, R2 = R3 = H; R1 = 5-OMe, 7-OMe, R2 = 8-OMe, R3 = H; R1 = 5-OMe, R2 = 6-OMe, R3 = 7-OMe; R1R2 = 6,7-OCH2O, R3 = H) were prepared by treating (EtO)2CHCO2Et with NH3, reducing (EtO)2CHCONH2, treating H2NCH2CH(OEt)2 with R1R2R3C6H2CHO followed by hydrogenation, and cyclizing R1R2R3C6H2CH2NHCH2CH(OEt)2 with RCHO. In the experiment, the researchers used many compounds, for example, 2,2-Diethoxyacetamide (cas: 61189-99-9SDS of cas: 61189-99-9).
2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.SDS of cas: 61189-99-9
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics