One-step synthesis of 4H-3,1-benzoxazin-4-ones from Weinreb amides and 1,4,2-dioxazol-5-ones via cobalt-catalyzed C-H bond activation was written by Tanimoto, Iku;Kawai, Kentaro;Sato, Akane;Yoshino, Tatsuhiko;Matsunaga, Shigeki. And the article was included in Heterocycles in 2019.Recommanded Product: 116332-61-7 This article mentions the following:
A one-step synthesis of 4H-3,1-benzoxazin-4-ones e.g., 2-phenyl-4H-benzo[d][1,3]oxazin-4-one from readily available Weinreb amides I (R = t-Bu, Ph, thiophen-2-yl, etc.) and 1,4,2-dioxazol-5-ones e.g., N-methoxy-N-methylbenzamide under Cp*Co(III) catalysis is described. The reactions proceeded in moderate to good yields with high functional group compatibility. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Recommanded Product: 116332-61-7).
N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Recommanded Product: 116332-61-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics