Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists was written by Mittapalli, Gopi Kumar;Vellucci, Danielle;Yang, Jun;Toussaint, Marion;Brothers, Shaun P.;Wahlestedt, Claes;Roberts, Edward. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Product Details of 383-31-3 This article mentions the following:
Highly potent and selective small mol. neuropeptide Y Y2 receptor antagonists are reported. The systematic SAR exploration of a hit mol. N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide, identified from HTS, led to the discovery of highly potent NPY Y2 antagonists 1-R-4-[hydroxy(diphenyl)methyl]piperidines [R = CSNHC6H4SO2NMe2-4] (CYM 9484) and [R = CO2C6H4SO2NEt2-4] (CYM 9552) with IC50 values of 19 nM and 12 nM resp. In the experiment, the researchers used many compounds, for example, 4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3Product Details of 383-31-3).
4-Fluoro-N,N-dimethylbenzenesulfonamide (cas: 383-31-3) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Product Details of 383-31-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics