Characterization, stability and solubility of co-amorphous systems of glibenclamide and L-arginine at different pH was written by Aragon-Aburto, Salma O.;Mondragn-Vasquez, Karina;Valerio-Alfaro, Gerardo;Dominguez-Chavez, Jorge G.. And the article was included in Tropical Journal of Pharmaceutical Research in 2022.Synthetic Route of C23H28ClN3O5S This article mentions the following:
To investigate the stability and solubility of co-amorphous systems of glibenclamide (GBC) with L-arginine (L-Arg) at different pH values. Three co-amorphous solids of GBC and L-Arg were obtained by fast solvent evaporation using 2:1, 1:1 and 1:2 stoichiometries. All co-amorphous systems were characterized by XRPD, FTIR, RAMAN and NMR-solid state as well as thermal techniques such as DSC and TGA. The stability of coamorphous systems was evaluated by indicative stability and stability in relevant physiol. media was measured at different pH values. The chem. characterization suggest that there was no proton transference between L-Arg and GBC indicative of co-amorphous solids. Stability studies showed that all the co-amorphous solids are unstable under humid conditions and only the co-amorphous system of GBC: L-Arg 1:2 was stable in all the pH values tested. Solubility studies at different pH values showed that the co-amorphous GBC: L-Arg 1:1 and 1:2, showed increasing solubility values even at pH > 7 (0.6468 mg/mL at pH 1.2 for coamorphous GBC: L-Arg 1:2 at the first hour) where free GBC was not soluble Co-amorphous systems of GBC and L-Arg, is an interesting strategy to increase the solubility of poorly-soluble drugs at acidic pH values. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Synthetic Route of C23H28ClN3O5S).
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Synthetic Route of C23H28ClN3O5S
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics