Indiplon: Treatment of insomnia GABA-A agonist was written by Sorbera, L. A.;Castaner, J.;Martin, L.. And the article was included in Drugs of the Future in 2003.HPLC of Formula: 325715-13-7 This article mentions the following:
Six different synthetic routes are investigated for the preparation of N-Methyl-N-[3-[3-[2-thienylcarbonyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]a cetamide (Indiplon) and its potential use as a drug for treatment of insomnia is evaluated. Indiplon is a GABA-A receptor partial agonist that promotes sleep by enhancing the inhibitory activity of GABA through specific binding to the BZ1 or α1 subunit of the GABA-A receptor. Indiplon has been shown to be safe and well tolerated and is currently being developed in two formulations to treat all insomnia complaints, including sleep initiation, night awakenings and total sleep maintenance. In the experiment, the researchers used many compounds, for example, N-(3-Acetylphenyl)-N-methylacetamide (cas: 325715-13-7HPLC of Formula: 325715-13-7).
N-(3-Acetylphenyl)-N-methylacetamide (cas: 325715-13-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.HPLC of Formula: 325715-13-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics