Multiple emulsions, a suitable vehicle to provide sustained release of cancer chemotherapeutic agents was written by Benoy, Christine J.;Elson, L. A.;Schneider, R.. And the article was included in British Journal of Pharmacology in 1972.Reference of 7413-34-5 This article mentions the following:
The antileukemic activity of a single dose of optimum Na methotrexate (I Na) [7413-34-5]-containing multiple emulsion formulation in mice was greater than that of a single I injection in aqueous solution or 5 daily aqueous injections at the same dose level. A single injection of cytosine arabinoside [147-94-4] in a multiple emulsion was as effective as 5 daily doses in aqueous solution Vincristine sulfate [2068-78-2] administered in a multiple emulsion increased for 48 hr the number of bone marrow cells arrested in metaphase compared with 4 hr after a single aqueous injection. In the experiment, the researchers used many compounds, for example, Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5Reference of 7413-34-5).
Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate (cas: 7413-34-5) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Reference of 7413-34-5
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics