Reference of 142733-64-0,Some common heterocyclic compound, 142733-64-0, name is tert-Butyl (cis-3-(hydroxymethyl)cyclobutyl)carbamate, molecular formula is C10H19NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of II-29-1 (200 mg, 1.0 mmol) and Et3N (202 mg, 2.0 mmol) in CH2C12(10 mL) was added MsCl (172 mg, 1.5 mmol) at 0 C. The reaction mixture was stirred at room temperature overnight before water was added to the reaction. The solution mixture was extracted with CH2C123 times. The organic layer was washed with brine and dried over Na2S04. The solution was filtered and concentrated to give II-29-2 as a white solid (250 mg, yield: 90%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl (cis-3-(hydroxymethyl)cyclobutyl)carbamate, its application will become more common.
Reference:
Patent; KURA ONCOLOGY, INC.; BURROWS, Francis; KESSLER, Linda V.; LI, Liansheng; REN, Pingda; WANG, Yi; WU, Tao; ZHANG, Jingchuan; (355 pag.)WO2018/175746; (2018); A1;,
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