Synthetic Route of 89979-12-4, These common heterocyclic compound, 89979-12-4, name is 5-Chloro-2-(methylsulfonamido)benzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of 5-chloro-N,6-dimethyl-2-[(1S)-1-(methylamino)propyl] pyrazolo[1,5-a] pyrimidin-7-amine (97 mg,0.361 mmol) and 5-chloro-2-(methylsulfonamido) benzoic acid(99 mg, 0.397 mmol) in N,N-dimethylformamide (1.0 mL)was added trimethylamine (0.25 mL, 1.80 mmol) and1-[bis(dimethylamino) methylene]-1H-1,2,3-triazolo[4,5-b]-pyridinium 3-oxide hexafluorophosphate (0.17 g, 0.433 mmol).After stirring at room temperature for 1 h, the reaction mixturewas purified by reversed-phase preparative HPLC toobtain 5-chloro-N-{(1S)-1-[5-chloro-6-methyl-7-(methylamino)-pyrazolo[1,5-a] pyrimidin-2-yl] propyl}-2-[(methanesulfonyl)-amino]-N-methylbenzamide (0.13 g, 0.904 mmol, 90%) as acolorless powder
The synthetic route of 89979-12-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yamaguchi-Sasaki, Toru; Tamura, Yunoshin; Ogata, Yuya; Kawaguchi, Takanori; Kurosaka, Jun; Sugaya, Yutaka; Iwakiri, Kanako; Busujima, Tsuyoshi; Takahashi, Ryo; Ueda-Yonemoto, Naoko; Tanigawa, Eiji; Abe-Kumasaka, Tomoko; Sugiyama, Hiroyuki; Kanuma, Kosuke; Chemical and Pharmaceutical Bulletin; vol. 68; 4; (2020); p. 345 – 362;,
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