Synthesis and antiviral effect of p-alkylbenzenesulfonamide derivatives was written by Tsuji, Tadakazu;Kawabata, Junzo;Kobayashi, Sachiko;Ueda, Takeo. And the article was included in Chemical & Pharmaceutical Bulletin in 1964.HPLC of Formula: 1146-43-6 This article mentions the following:
p-Alkylbenzenesulfonamide derivatives were synthesized by the reaction of p-alkyl- or p-alkoxybenzenesulfonyl chloride with amine or ammonia, and the compounds were recrystallized from dilute EtOH. Lower alkyl and alkoxyl groups introduced into benzenesulfonamide gave rise to in vitro activity on poliomyelitis virus (Lansing strain). Mice were inoculated intracerebrally with poliomyelitis virus prior to intravenous injections of the tested derivative Only p-toluenesulfonamide and N-phenyl-p-toluenesulfonamide showed in vivo activity on viral multiplication. N-Phenyl-p-toluenesulfonamide required repeated daily administrations of 11 mg./kg. for 3-5 days to demonstrate effectiveness. None of the derivatives was effective against Japanese encephalitis (Nakayma strain) or influenza A virus (PR-8 strain). In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6HPLC of Formula: 1146-43-6).
N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.HPLC of Formula: 1146-43-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics