Toogood, Peter L. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 1996 | CAS: 61189-99-9

2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.HPLC of Formula: 61189-99-9

A formal synthesis of althiomycin was written by Toogood, Peter L.;Hollenbeck, Jessica J.;Lam, Huong M.;Li, Li. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1996.HPLC of Formula: 61189-99-9 This article mentions the following:

The thiazolecarboxylate and amine fragments previously used in the preparation of althiomycin were prepared in a formal synthesis of althiomycin for studies of its interaction with prokaryotic ribosomes. In the experiment, the researchers used many compounds, for example, 2,2-Diethoxyacetamide (cas: 61189-99-9HPLC of Formula: 61189-99-9).

2,2-Diethoxyacetamide (cas: 61189-99-9) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.HPLC of Formula: 61189-99-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics