Zhang, Han-Cheng et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2004 | CAS: 10268-06-1

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Electric Literature of C8H8ClNO

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3 was written by Zhang, Han-Cheng;Ye, Hong;Conway, Bruce R.;Derian, Claudia K.;Addo, Michael F.;Kuo, Gee-Hong;Hecker, Leonard R.;Croll, Diane R.;Li, Jian;Westover, Lori;Xu, Jun Z.;Look, Richard;Demarest, Keith T.;Andrade-Gordon, Patricia;Damiano, Bruce P.;Maryanoff, Bruce E.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Electric Literature of C8H8ClNO This article mentions the following:

A novel series of acyclic 3-(7-azaindolyl)-4-(aryl/heteroaryl)maleimides, e.g., I and II, was synthesized and evaluated for activity against GSK-3β and selectivity vs. PKC-βII, as well as a broad panel of protein kinases. Compounds I and II potently inhibited GSK-3β (IC50=7 and 26 nM, resp.) and exhibited excellent selectivity over PKC-βII (325 and >385-fold, resp.). Compound I was also highly selective against 68 other protein kinases. In a cell-based functional assay, both I and II effectively increased glycogen synthase activity by inhibiting GSK-3β. In the experiment, the researchers used many compounds, for example, 2-(2-Chlorophenyl)acetamide (cas: 10268-06-1Electric Literature of C8H8ClNO).

2-(2-Chlorophenyl)acetamide (cas: 10268-06-1) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Electric Literature of C8H8ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics