Reference of 85006-25-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 85006-25-3, name is tert-Butyl (tert-butoxycarbonyl)oxycarbamate, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of tert-butyl (tert-butoxycarbonyl) oxycarbamate (2.71 g, 11.64 mmol) and 1- (bromomethyl) -4-fluorobenzene (2 g, 10.58 mmol) in DCM To the solution was added NaOH (11.64 mL, 11.64 mmol) followed by tetrabutylammonium bromide (3.41 g, 10.58 mmol) and stirred overnight at room temperature. Water (100 mL) was added to the reaction mixture, and the product was extracted with ethyl acetate (3 * 100 mL), and the combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated to give 5.5 g of crude material. The crude material was purified by Iscor using a 40 g silica gel column and the product was eluted with 10% ethyl acetate in petroleum ether to give tert-butyl (tert-butoxycarbonyl) oxy (4-fluorobenzyl) carbamate (3.1 g, 8.99 mmol, 85% yield) as a colorless sticky material.
The chemical industry reduces the impact on the environment during synthesis tert-Butyl (tert-butoxycarbonyl)oxycarbamate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Beu Lease Tol-mai Ground Wire Seukwp Keompeoni; I Seul-ram-, -i-ma-dul; Tang Ga-ti-ru-pa-ti-, -seu-ri-ni-ba-san; Wa Ri-e-reu-, -ja-ya-ku-ma-reu-san-ka-ra; Che Ru-ku-, -seu-ri-ni-ba-seu; Sye Ti-, -pu-reu-ni-ma; Ma Ko-reu-, -jon-i-.; (44 pag.)KR2018/64507; (2018); A;,
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