Izuchukwu, Ugwuja Daniel et al. published their research in Pakistan Journal of Pharmaceutical Sciences in 2018 | CAS: 1146-43-6

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide

Synthesis of N-aryl substituted p-toluenesulphonamides via nickel catalyzed amidation reaction and their antibacterial, antifungal and antioxidant activities evaluation was written by Izuchukwu, Ugwuja Daniel;Chris, Okoro Uchechukwu;Izuchukwu, Ugwu David. And the article was included in Pakistan Journal of Pharmaceutical Sciences in 2018.Recommanded Product: N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide This article mentions the following:

In present study nickel catalyzed synthesis of N-(aryl) substituted p-toluene sulfonamides is reported. Substituted p-toluene sulfonamides were obtained by coupling 4-methylbenezenesulfonamide with various readily available aryl halides via Buchwald-Hartwig cross-coupling reaction. The new compounds were screened for antibacterial and antifungal activities against Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coll, Staphylococcus aureus, salmonella typhi, candida albicans and Aspergillus niger using agar diffusion technique. The sulfonamides were further screened for antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl, Ferrous sulfate lipid per oxidation and Ferric reducing antioxidant power. Tests such as acute toxicity, liver function and kidney function was also carried out on the synthesized compounds In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Recommanded Product: N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics