Moccia, Maria published the artcilePreliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks, Computed Properties of 186046-83-3, the publication is Journal of Peptide Science (2009), 15(10), 647-653, database is CAplus and MEDLINE.
In this work, the authors report thermodn., kinetic, and microrheol. studies relative to the formation of PNA- and PNA/DNA-based noncovalent polymeric systems, useful tools for biotechnol. and bioengineering applications. The authors realized two kinds of systems: a PNA-based system formed by a self-assembling PNA tridendron, and a PNA/DNA hybrid system formed by a PNA tridendron and a DNA linker. The formation of a three-dimensional polymeric network, by specific Watson-Crick base pairing, was investigated by a detailed UV and CD spectroscopic study. Preliminary microrheol. experiments were performed on both systems to evaluate their viscoelastic properties which resulted in agreement with the formation of soluble hyperbranched polymers that could be useful for drug/gene delivery, as well as for encapsulating organic pollutants of different shapes and sizes in environmental applications. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.
Journal of Peptide Science published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Computed Properties of 186046-83-3.
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