Kayser, Kevin published the artcileASD Formation Prior to Material Characterization as Key Parameter for Accurate Measurements and Subsequent Process Simulation for Hot-Melt Extrusion, Product Details of C17H14F3N3O2S, the publication is AAPS PharmSciTech (2022), 23(6), 176, database is CAplus and MEDLINE.
Process simulation facilitates scale-up of hot-melt extrusion (HME) and enhances proper understanding of the underlying critical process parameters. However, performing numeric simulations requires profound knowledge of the employed materials’ properties. For example, an accurate description of the compounds’ melt rheol. is paramount for proper simulations. Hence, sample preparation needs to be optimized to yield results as predictive as possible. To identify the optimal preparation method for small amplitude oscillatory shear (SAOS) rheol. measurements, binary mixtures of hydroxypropylmethylcellulose acetate succinate or methacrylic acid Et acrylate copolymer (Eudragit L100-55) together with the model drugs celecoxib and ketoconazole were prepared The phys. powder mixtures were introduced into the SAOS as a compressed tablet or a disk prepared via vacuum compression molding (VCM). Simulations with the derived parameters were conducted and compared to lab-scale extrusion trials. VCM was identified as the ideal preparation method resulting in the highest similarity between simulated and exptl. values, while simulation based on conventional powder-based methods insufficiently described the HME process.
AAPS PharmSciTech published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Product Details of C17H14F3N3O2S.
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