Tisler, M. published the artcileSyntheses of some N-substituted thiocarbamylpiperidines and thiocarbamylmerpholines, Recommanded Product: Morpholine-4-carbothioamide, the publication is Croatica Chemica Acta (1957), 409-11, database is CAplus.
RCNS (0.02 mole) in 10 ml. Et2O added to an ice-cold solution of 0.02 mole piperidine or morpholine in 10 ml. Et2O, kept 15 min., the solution filtered and the precipitate crystallized (EtOH or aqueous EtOH) gave 82-90% XCSNHR [R, m.p., and EtOH-H2O ratio for crystallization given]: (Χ = piperidino) 2,3-Me2C6H3, 138°, 3:1; 2,4-Me2C6H3, 119°, 1:1; 2,5-Me2C6H3, 118°, 2:1; 2-MeOC6H4, 61°, 2:1; 4-MeOC6H4, 146°, 3:1; 3-ClC6H4, 135°, 1:0; 4-Me2NC6H4 (I), 129°, 1:1; C6H12, 133°, 3:1; Ph, 99°, -; 2-MeC6H4, 98°, -; 3-MeC6H4, 102°, -; 4-MeC6H4, 134°, -; 4-ClC6H4, 153°, -; 4-BrC6H4, 166°, -; PhCH2, 88°, -; 1-C10H7, 125°, -; Me, 131°, -; (Χ = morpholino) Ph, 134°, 1:0; 2-MeC6H4, 144°, 1:0; 2-MeOC6H4, 91°, 1:1; 2,3-Me2C6H3, 147°, 1:0; 2,4-Me2C6H3, 148°, 1:0; 2,5-Me2C6H3, 156°, 1:0; 3-ClC6H4, 162°, 1:0; 4-Me2NC6H4, 170°, 1:0; PhCH2, 100°, 3:1; C6H12, 136°, 2:1. Tested against M. tuberculosis H37Rv strain on liquid Sula medium only I showed complete inhibition at 5 γ/ml.
Croatica Chemica Acta published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C7H7N3, Recommanded Product: Morpholine-4-carbothioamide.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics