Haggam, Reda A. published the artcileMicrowave-assisted synthesis of double-headed derivatives of 1,2-bis(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)ethan-1-ol and study of their biological activity, SDS of cas: 79-07-2, the publication is Research on Chemical Intermediates (2021), 47(9), 3733-3749, database is CAplus.
Rapid and efficient synthesis of a series of some novel derivatives of 1,2-bis(4-amino-5-mercapto-1,2,4-triazol-3-yl)ethan-1-ol (I), prepared from thiocarbohydrazide and dl-malic acid under microwave (MW) irradiation, is described. Reactions of I with several alkylating agents, such as epichlorohydrin, 3-chloro-1-propanol, (2-acetoxyethoxy)methyl bromide, propargyl bromide, chloroacetamide, etc., as well as cyclization reactions with α-bromoacetophenone, benzoyl isothiocyanate, chloroacetyl chloride, succinic anhydride, etc. were studied. Higher yields and shorter reaction times were observed under microwave irradiation conditions in comparison to conventional heating procedures. The structures of the obtained products were established based on their 1H/13C NMR, IR, elemental anal. and correlation experiments The synthesized compounds were screened for their antifungal activities. The minimal inhibitory concentration (MIC) of the screened compounds showed significant activity of several compounds against Gram (+ve) and Gram (-ve) bacteria and antifungal activity compared to the standard drugs.
Research on Chemical Intermediates published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, SDS of cas: 79-07-2.
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