Abu-Hashem, Ameen Ali published the artcileSynthesis of new pyrazoles, oxadiazoles, triazoles, pyrrolotriazines, and pyrrolotriazepines as potential cytotoxic agents, Safety of 2-Chloroacetamide, the publication is Journal of Heterocyclic Chemistry (2021), 58(3), 805-821, database is CAplus.
The 4-oxo-4-phenylbutanehydrazide reacted with many active methylene reagents such as acetylacetone, diethylmalonate, ethylacetoacetate, ethylcyanoacetate, benzoyl-acetonitrile, and malononitrile under neat conditions to afford the corresponding pyrazoles e.g., I, also, treatment of 4-oxo-4-phenylbutanehydrazide with electrophilic reagents as triethylorthoformate, dimethylformamide-dimethylacetal, acetic anhydride, and carbon disulfide to give 1,3,4-oxadiazoles e.g., II and N’-acetyl-4-oxo-4-phenylbutanehydrazide. Reaction of 4-oxo-4-phenylbutanehydrazide with potassium thiocyanate gave 1-phenyl-3-(5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propan-1-one. Similarly, treatment of 4-oxo-4-phenylbutanehydrazide with chloroacetamide gave 3-(3-oxo-3-phenylpropyl)-1,6-dihydro-1,2,4-triazin-5(2H)-one. The 6-phenyl-3,4-dihydropyrrolo[1,2-b][1,2,4]triazin-2(8H)-one was obtained by cyclization of 3-(3-oxo-3-phenylpropyl)-1,6-dihydro-1,2,4-triazin-5(2H)-one. Also, 4-oxo-4-phenylbutanehydrazide was utilized as a starting material for the synthesis of new Schiff bases as N’-(4-sub-benzylidene)-phenylbutane-hydrazides C6H5C(O)(CH2)2C(O)NHN=CHAr (Ar = Ph, 4-chlorophenyl, 4-methoxyphenyl), which are used as an initiative to prepare new compounds such as 1,2,4-triazepinones III, pyrrolotriazepinones IV, 1,2,4-triazines V, and pyrrolotriazines VI by reaction of N’-(4-sub-benzylidene)-phenylbutane-hydrazides with each chloroacetamide or formamide. The prepared compounds were tested for their in vitro antitumor activities. The compounds III, IVand VI displayed activity against several types of cancer cell lines.
Journal of Heterocyclic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Safety of 2-Chloroacetamide.
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