Wang, Jiawen published the artcileChiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies, Computed Properties of 2418-95-3, the publication is Nature Communications (2020), 11(1), 5527, database is CAplus and MEDLINE.
Here-in, an enantioselective and diastereodivergent synthesis of trisubstituted allenes I (R = Et, nBu, Bn, etc.; R1 = nBu, Ph, thiophen-3-yl, etc.; R2 = Ph, 4-chlorophenyl, cyclohexyl, etc.; R3 = Me, Et, n-Pr, n-Bu, i-Bu) and II by asym. additions of oxazolones III to activated 1,3-enynes R2CH:C(CCR1)C(O)R3 enabled by chiral phosphoric acid (CPA) catalysis where the divergence of the allenic axial stereogenicity is realized by modifications of CPA catalysts was reported. D. functional theory (DFT) calculations are performed to elucidate the origin of diastereodivergence by the stacking- and stagger-form in the transition state (TS) of allene formation step, as well as to disclose a Munchnone-type activation mode of oxazolones II under Bronsted acid catalysis.
Nature Communications published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C3H6O2, Computed Properties of 2418-95-3.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics