Dai, Hong published the artcileSynthesis and biological activity of 1-{4-[(2-cyanoimino-1,3-thiazolidine-3-yl)methyl]thiazol-2-yl}-3-aroyl ureas, Safety of 2,4-Dichlorobenzamide, the publication is Youji Huaxue (2013), 33(7), 1568-1572, database is CAplus.
In search of novel thiazole derivatives with potent biol. activities, a series of new thiazole compounds I (R = 4-Me, 4-Et, 3-F, 4-F, 2-Cl, 4-Cl, 4-Br, 2,4-Cl2, 3,4-Cl2) containing acyl urea moiety were synthesized by the condensation of 2-cyanoimino-3-(2-aminothiazol-4-ylmethyl)thiazolidine with various arylacylisocyanates. The structures of the target compounds were determined by 1H NMR, MS and elemental anal. The structures of I (R = 4-Me, 2-Cl, 2,4-Cl2) were further characterized by 13C NMR spectra. The bioassay data indicated that some of the title compounds showed fungicidal activities to some extent at the concentration of 50 μg/mL. For example, compound I (R = 4-F)displayed 65.3% inhibition rate against Gibberella zeae, compound I (R = 4-Cl) exhibited 67.3% inhibition rate against Cercospora arachidicola, and compound I (R = 4-Br) showed 56.1% inhibition rate against Physalospora piricola.
Youji Huaxue published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Safety of 2,4-Dichlorobenzamide.
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https://en.wikipedia.org/wiki/Amide,
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