Berger, Or published the artcileSpectral Transition in Bio-Inspired Self-Assembled Peptide Nucleic Acid Photonic Crystals, Quality Control of 186046-83-3, the publication is Advanced Materials (Weinheim, Germany) (2016), 28(11), 2195-2200, database is CAplus and MEDLINE.
Guanine-containing short sequences of peptide nucleic acids (PNAs), synthetic nucleic acid analogs with an amide backbone, can self-assemble into ordered structures with unique optical properties. These observations prompted examination as to whether PNA monomers can also undergo a process of self-association and organization into supramol. assemblies, as it had previously been shown that even a single amino acid can self-assemble into fibrils with well-ordered electron diffraction. The 4 PNA monomers were tested for their ability to self-assemble into ordered structures under a variety of conditions including organic solvents (MeOH, EtOH, DMSO, and hexafluoro-2-propanol) and diverse buffer solutions with a range of pH values and concentrations The monomers were examined with or without the addnl. protecting groups, fluorenylmethyloxycarbonyl (Fmoc) and benzhydryloxycarbonyl (Bhoc), which are conjugated to the building blocks used for solid phase synthesis of PNA oligomers. Assembly into ordered structures was evident solely for N-(N-Fmoc-2-aminoethyl)-N-[(N-6-Bhoc-9-guanyl)acetyl]glycine (Fmoc-G-(Bhoc)-aeg-OH) in H2O. Aromatic protecting groups are known to promote self-assembly of short peptides. The Fmoc moiety has a significant impact on the assembly of aromatic peptide amphiphiles. The PNA monomers could be considered as amphiphiles with the protecting groups serving as lipophilic moieties and the guanine base as the hydrophilic component.
Advanced Materials (Weinheim, Germany) published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Quality Control of 186046-83-3.
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https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics