Ozaki, Tomoya published the artcileLate-stage sulfonic acid/sulfonate formation from sulfonamides via sulfonyl pyrroles, Synthetic Route of 169590-42-5, the publication is Tetrahedron (2022), 132830, database is CAplus.
An accessible and low-cost route for transforming primary sulfonamides into the corresponding sulfonic acids/sulfonates RSO2OH·Et3N [R = 4-MeC6H4, 4-H2NC6H4, 4-O2NC6H4, [4-[2-[(4-ethyl-3-methyl-5-oxo-2H-pyrrole-1-carbonyl)amino]ethyl]phenyl]], R1SO2OK [R1 = Et, 4-MeOC6H4, Bn, etc.] via sulfonyl pyrroles R1SO2R2 [R1 = Et, t-Bu, Bn, etc.; R2 = pyrrol-1-yl] was reported. The reaction was demonstrated with a range of substrates including aryl and alkyl sulfonamides, and in the late-stage functionalization of several sulfonamide-containing drug mols.
Tetrahedron published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Synthetic Route of 169590-42-5.
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