Reference of 683-57-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 683-57-8, name is 2-Bromoacetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 5-bromo-2-hydroxybenzonitrile 1 (1O g, 50.5 mmol) in 50 mL acetone was added potassium carbonate (13.8 g, 100 mmol) and 2- bromoacetamide (6.9 g, 50.5 mmol). The reaction mixture was heated to 60 0C for 18 hours. After cooling, the solids were filtered off and dissolved in a large excess of water (1000 mL). The white solid was collected and dried to afford 11.2 g (89%) of 2- (4-bromo-2-cyanophenoxy)acetamide 2 as a white solid. 1H NMR (400 MHz, d6- DMSO): 8.03 (d, IH), 7.83 (dd, IH), 7.53 (br s, 1 H), 7.45 (br s, IH), 7.03 (d, IH), 4.7 (s, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromoacetamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; EXELIXIS, INC.; WO2009/86264; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics