Paul, Alexis published the artcileCombining G-quadruplex targeting motifs on a single peptide nucleic acid scaffold: a hybrid (3 + 1) PNA-DNA bimolecular quadruplex, Application In Synthesis of 186046-83-3, the publication is Chemistry – A European Journal (2008), 14(28), 8682-8689, database is CAplus and MEDLINE.
We describe the 1st G-quadruplex targeting approach that combines intercalation and hybridization strategies by investigating the interaction of a G-rich peptide nucleic acid (PNA) acridone conjugate with a 3-repeat fragment of the human telomere G3 to form a hybrid PNA-DNA quadruplex that mimics the biol. relevant (3 + 1) pure DNA dimeric telomeric quadruplex. Using a combination of UV and fluorescence spectroscopy, CD, and mass spectrometry, we show that PNA can induce the formation of a bimol. hybrid quadruplex even at low salt concentration upon interaction with a single-stranded 3-repeat fragment of telomeric DNA. However, PNA cannot invade a short fragment of B-DNA even if the latter contains a CCC motif complementary to the PNA sequence. These studies could open up new possibilities for the design of a novel generation of quadruplex ligands that target not only the external features of the quadruplex but also its central core constituted by the tetrads themselves.
Chemistry – A European Journal published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Application In Synthesis of 186046-83-3.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics