Anilkumar, Gopinadhan N. published the artcileII. Novel HCV NS5B polymerase inhibitors: discovery of indole C2 acyl sulfonamides, COA of Formula: C7H8FNO2S, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(1), 713-717, database is CAplus and MEDLINE.
Development of SAR at the C2 position of indole lead I, a palm site inhibitor of HCV NS5B polymerase (NS5B IC50 = 0.053 μM, replicon EC50 = 4.8 μM), is described. Initial screening identified an acyl sulfonamide moiety as an isostere for the C2 carboxylic acid group. Further SAR investigation resulted in identification of acyl sufonamide analog II (NS5B IC50 = 0.039 μM, replicon EC50 = 0.011 μM) with >100-fold improved replicon activity.
Bioorganic & Medicinal Chemistry Letters published new progress about 489-17-8. 489-17-8 belongs to amides-buliding-blocks, auxiliary class Fluoride,Sulfamide,Amine,Benzene, name is 4-Fluoro-2-methylbenzenesulfonamide, and the molecular formula is C7H8FNO2S, COA of Formula: C7H8FNO2S.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics