Schaefer, Olga published the artcileInvestigation of α-amino acid N-carboxyanhydrides by X-ray diffraction for controlled ring-opening polymerization, SDS of cas: 2418-95-3, the publication is Tetrahedron Letters (2019), 60(3), 272-275, database is CAplus.
The need for a scalable synthesis of not sequence defined polypeptides as biomaterials is met by the ring-opening polymerization of α-amino acid N-carboxyanhydrides (NCAs). Even though this polymerization technique appears straight forward, it holds pitfalls in terms of reproducibility and overall control over the polymerization conditions, which depends, beside choice of solvent or initiator, significantly on reagent purity. In addition, the synthesis of monomers can lead to the formation of racemic amino acids. Thus, in this work, we describe the benefits of highly pure monomers in order to control nucleophilic ring-opening polymerization NCAs. Hereby, monomer purity is investigated by relating m.ps. of NCAs with single-crystal and powder X-ray diffraction crystallog. data, which further proves retained stereo-information of NCAs.
Tetrahedron Letters published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, SDS of cas: 2418-95-3.
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