Pasquinet, Eric published the artcileFirst Total Synthesis of Phenylpyridine Analogues of the Antimitotic Rhazinilam, Application of (2-Pivalamidophenyl)boronic acid, the publication is Journal of Organic Chemistry (2001), 66(8), 2654-2661, database is CAplus and MEDLINE.
The first synthesis of phenylpyridine analogs of rhazinilam, e.g. I, and evaluation of these new structures as inhibitors of microtubule disassembly by interaction with tubulin are described. The synthesis is based on such key steps as picolinic metalation, hetero-ring cross-coupling and reduction of an acetyl group to an Et group. Elaboration of a quaternary picolinic carbon is one of the challenges of the synthesis. Biol. evaluation of compounds bearing a quaternary picolinic carbon showed interactions with tubulin similar to (-)-rhazinilam but at a lower level.
Journal of Organic Chemistry published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Application of (2-Pivalamidophenyl)boronic acid.
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