Godard, A. published the artcileMetalation in connection with cross-coupling reactions. Coupling of hindered aryls for the synthesis of 4-phenylpyridines as part of Streptonigrin and Lavendamycin analogs, Synthetic Route of 146140-95-6, the publication is Journal of Organometallic Chemistry (1996), 517(1-2), 25-36, database is CAplus.
The synthesis of the C-D ring system of Streptonigrin and Lavendamycin alkaloid analogs by cross-coupling under Suzuki’s conditions has been studied. Steric hindrance is the main problem. It has been solved either by using strong bases or working in a sealed tube under pressure.
Journal of Organometallic Chemistry published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Synthetic Route of 146140-95-6.
Referemce:
https://en.wikipedia.org/wiki/Amide,
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