Robson, John H.’s team published research in Journal of the American Chemical Society in 77 | CAS: 360-92-9

Journal of the American Chemical Society published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, COA of Formula: C6H10F3NO.

Robson, John H. published the artcileThe infrared spectra of N-substituted trifluoroacetamides, COA of Formula: C6H10F3NO, the publication is Journal of the American Chemical Society (1955), 498-9, database is CAplus.

Et2NH (14.6 g.) in 100 cc. Et2O cooled to -10°, treated with 14 cc. (CF3CO)2O, and the mixture warmed to room temperature, washed with H2O, dried, and fractionated gave 11.7 g. CF3CONEt2, b24 65-7°, nD24 1.3782. Similarly were prepared the following CF3CONHR (R, b.p./mm., m.p., and nD25 given): iso-Pr, 71-2°/20.5, 51.0-2.3° (from hexane), -; Bu, 100-1°/28.5, -, 1.3805; and the amides CF3CONR2: iso-Pr, -, 52-2.5°, -; Bu, 106°/16.0, -, 1.3997; iso-Bu, 89.0-9.5°/13.4, -, 1.4017. By conventional methods were prepared the following AcNR2 (same data given): Et, 179-81°/700, (88.5-91.0°/31.0), -, 1.4333; Pr, 94.5°/12.0, -, 1.4411; Bu, 238°/705, (116.5°/8.0), -, 1.4451. (iso-Bu)2NH (106 cc.) added to 240 cc. purified Ac2O, the mixture heated to 110°, and 170 cc. AcOH and excess Ac2O distilled off yielded 75.3 g. (iso-Bu2)NAc, b0.8 102.5-103.0, nD25 1.4434; it was reported previously by Chute, et al. (C.A. 42, 4919b), to be a solid, m. 74°, which was probably (iso-Bu)2NNO2. HCONHEt2, b15.0 69°, nD25 1.4296, was prepared by the method of Ott, et al. (C.A. 37, 5014.3). (Me2CH)2NH (101 g.) added below 60° to 46.0 g. 98-100% HCO2H in 200 cc. m-xylene, the mixture refluxed 48 hrs. with the H2O of reaction removed continuously, and the homogeneous solution fractionated gave 54.0 g. HCON(CHMe)2, b23.5 93-3.8°, m. 11.6°, nD25 1.4371. Similarly were prepared HCONPr2, b715 206-7°, nD25 1.4384 (could not be crystallized at -70°), and HCONBu2, b7.8 101°, nD20 1.4400. The infrared absorption maximum of the compounds described are tabulated.

Journal of the American Chemical Society published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, COA of Formula: C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics