Nokihara, Kiyoshi published the artcileImproved coupling methods for the difficult amide-bond formation in solid-phase assembly, Formula: C40H35N7O8, the publication is Peptide Science (2013), 167-170, database is CAplus.
A symposium report. In the solid-phase peptide synthesis certain peptides are difficult to assemble because of steric hindrance and aggregation of mols., more over in such case removal of Nα-Fmoc group (Fmoc = 9-fluorenylmethoxycarbonyl) is also hindered. Yield and purity of desired peptides after cleavage are important for economical aspects, especially amide bond formation with costly unnatural amino acids as building blocks. The present report describes amide bond formation by elevated temperature to overcome poor coupling efficiency and to realize shorter coupling times. Addnl. racemization during Fmoc-removal at elevated temperature is also investigated.
Peptide Science published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Formula: C40H35N7O8.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics