Zarudnitskii, E. V. published the artcileC-phosphorylation of 2-dialkylaminothiazole and imidazo[2,1-b]thiazole derivatives, Formula: C5H10N2OS, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (2002), 68(11-12), 38-42, database is CAplus.
Phosphorylation of 2-dialkylaminothiazole derivatives with PCl3, Ph2PCl and Ph2PBr was studied. Reaction of 2-diethylaminothiazole with R2PCl gave 2-Et2N-5-PR2(C3HNS) (2 R = Cl, 3 R = Ph). Phosphination of Et 2-diethylaminothiazolecarboxylate (4) with Ph2PBr gave 5-PPh2 derivative (5), which was hydrolyzed to free acid (6). Thiazoleacetates 2-R2N(C3HNS)-4-CH2COOEt were also phosphinated in position 5 to give 2-R2N(C3NS)-4-CH2COOEt-5-PPh2 (8a–c, R = Me, Et, or R2N = morpholino), which were hydrolyzed to free acids (9a–c). In contrast to esters of 2-dialkylamino-4-thiazoleacetic acids, Et ester of 6-imidazo[2,1-b]thiazoleacetic acid undergoes C-phosphination with Ph2PCl both at heterocycle and at methylene group.
Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C8H11NO, Formula: C5H10N2OS.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics