Pejman, Laleh published the artcileThe effect of adenosine A2A and A2B antagonists on tracheal responsiveness, serum levels of cytokines and lung inflammation in guinea pig model of asthma, Formula: C27H29N5O5, the publication is Advanced Pharmaceutical Bulletin (2014), 4(2), 131-138, 8 pp., database is CAplus and MEDLINE.
Nowadays adenosine is specified as an important factor in the pathophysiol. of asthma. For determining the effect of different A2 receptors, in this investigation the effect of single dose of selective adenosine A2A and A2B antagonists (ZM241385 and MRS1706) on different inflammatory parameters; tracheal responsiveness to methacholine and ovalbumin, total and differential cell count in bronchoalveolar lavage (BAL), blood levels of IL-4 and IFN-γ and lung pathol. of guinea pig model of asthma were assessed. All mentioned parameters were evaluated in 2 sensitized groups of guinea pigs pretreated with A2A and A2B antagonists (S+Anta A2A, S+Anta A2B) compared with sensitized (S) and control (C) groups. The tracheal responsiveness to methacholine and OA, total cell and eosinophil and basophil count in BAL, blood IL-4 level and pathol. changes in pretreated group with MRS1706 (S+Anta A2B) was significantly lower than those of sensitized group. In pretreated group with Anta A2A(S+Anta A2A), all the above changes were reversed. These results showed a preventive effect of A2B antagonist (MRS1706) on tracheal responsiveness to methacholine and OA, total and differential cell count in bronchoalveolar lavage, blood cytokines and pathol. changes. Administration of ZM241385, selective A2A antagonist, deteriorated the induction effect of ovalbumin.
Advanced Pharmaceutical Bulletin published new progress about 264622-53-9. 264622-53-9 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Adenosine Receptor, name is N-(4-Acetylphenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide, and the molecular formula is C27H29N5O5, Formula: C27H29N5O5.
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