Matulenko, Mark A. published the artcile5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors, HPLC of Formula: 14294-10-1, the publication is Bioorganic & Medicinal Chemistry (2005), 13(11), 3705-3720, database is CAplus and MEDLINE.
4-Amino-5,7-disubstituted pyridopyrimidines are potent, non-nucleoside inhibitors of adenosine kinase (AK). The authors recently identified a potent, orally efficacious analog I containing a 7-pyridylmorpholine substituted ring system as the key structural element of this template. The pharmacol. effects of five- and six-membered heterocyclic ring replacements for the pyridine ring in I are reported. These replacements were found to have interesting effects on in vivo efficacy and genotoxicity as well as in vitro potency. The authors discovered that the nitrogen in the heterocyclic ring at C(7) is important for the modulation of mutagenic side effects (Ames assay).
Bioorganic & Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, HPLC of Formula: 14294-10-1.
Referemce:
https://en.wikipedia.org/wiki/Amide,
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