Copper-catalyzed one-pot synthesis of N-substituted benzo[d]isothiazol-3(2H)-ones via C-S/N-S bond formation was written by Paul, Rajesh;Punniyamurthy, Tharmalingam. And the article was included in RSC Advances in 2012.Name: N-Benzyl-2-chloro-5-nitrobenzamide The following contents are mentioned in the article:
A one-pot synthesis of N-substituted benzo[d]isothiazol-3(2H)-one derivatives was described using copper-catalysis and N-substituted 2-halobenzamides and sulfur powder by a C-S/N-S bond formation with high yield. The title compounds thus formed included 5-methoxy-2-(phenylmethyl)-1,2-benzisothiazol-3(2H)-one (I) and related substances. The synthesis of the target compound was achieved by a copper chloride (CuCl) catalyzed reaction of sulfur with 2-iodo-5-methoxy-N-(phenylmethyl)benzamide. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Name: N-Benzyl-2-chloro-5-nitrobenzamide).
N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Name: N-Benzyl-2-chloro-5-nitrobenzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics