An efficient copper mediated synthetic methodology for benzo[d]isothiazol-3(2H)-ones and related sulfur-nitrogen heterocycles was written by Bhakuni, Bhagat Singh;Balkrishna, Shah Jaimin;Kumar, Amit;Kumar, Sangit. And the article was included in Tetrahedron Letters in 2012.COA of Formula: C14H11ClN2O3 The following contents are mentioned in the article:
A copper mediated sulfur-nitrogen coupling reaction for the synthesis of benzo[d]isothiazol-3(2H)-ones and related sulfur-nitrogen heterocycles has been presented, which requires 2-halo arylamides, sulfur powder, 25-50 mol % of copper iodide/1,10-phenanthroline, and potassium carbonate as base. E.g., in presence of copper iodide/1,10-phenanthroline and sulfur powder, sulfur-nitrogen coupling reaction of 2-chloro-, 2-bromo-, and 2-iodo-N-benzylbenzamides gave benzo[d]isothiazol-3(2H)-one (I) in 47-89% yields. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7COA of Formula: C14H11ClN2O3).
N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.COA of Formula: C14H11ClN2O3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics