Cu-Catalyzed Efficient Synthetic Methodology for Ebselen and Related Se-N Heterocycles was written by Balkrishna, Shah Jaimin;Bhakuni, Bhagat Singh;Chopra, Deepak;Kumar, Sangit. And the article was included in Organic Letters in 2010.Related Products of 83909-69-7 The following contents are mentioned in the article:
An efficient copper-catalyzed method for the synthesis of biol. important ebselen and related analogs containing a Se-N bond has been developed. This is the first report of a catalytic process of selenation and Se-N bond formation reaction. The copper-catalyzed reaction tolerates functional groups such as amides, hydroxyls, ethers, nitro, fluorides, and chlorides. The best results are obtained by using a combination of potassium carbonate as a base, iodo- or bromo-arylamide substrates, selenium powder, and copper iodide catalyst. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Related Products of 83909-69-7).
N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Related Products of 83909-69-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics