Synthesis and biological activity of 2,5-diaminobenzoic acids stimulating the biosynthesis of prostaglandins was written by Kosary, J.;Szabo, I. K.;Kasztreiner, E.. And the article was included in Pharmazie in 1982.Quality Control of N-Benzyl-2-chloro-5-nitrobenzamide The following contents are mentioned in the article:
Twenty-two diaminobenzoates [I; R = NH2; R1 = OH, OMe, OEt, NH2, cyclopropylamino, PhCH2NH, Et2N(CH2)2NH; R2 = cyclopropyl, Bu, cyclohexyl, aryl, Et2N(CH2)2; R3 = H, Bu; or NR2R3 = morpholino] (II) were prepared by reduction (H, Pd/C) of the corresponding I (R = NO2). II are potent activators of prostaglandin synthetase (from sheep seminal vesicles) and play an important role in the biosynthesis of prostaglandins. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Quality Control of N-Benzyl-2-chloro-5-nitrobenzamide).
N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Quality Control of N-Benzyl-2-chloro-5-nitrobenzamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics