Metal-free C-H methylation and acetylation of heteroarenes with PEG-400 was written by Kudale, Vishal Suresh;Wang, Jeh-Jeng. And the article was included in Green Chemistry in 2020.Electric Literature of C13H11BrN2O The following contents are mentioned in the article:
A novel and an efficient route for synthesis of methyl-arylquinazolinones I [R = H, 8-Me, 7-Cl; R1 = Ph, 4-MeOC6H4, 2-ClC6H4, etc.] and acetylated heteroarenes II [Ar = 2-quinolyl, 3-CN-2-pyridyl, 1,3-benzothiazol-2-yl, etc.] via methylation and acetylation of aza-heteroarenes using PEG-400 under O2 and TsOH·H2O for the first time by tuning the reaction conditions using a different set of starting materials was described. The key features of current protocol were oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance and a broad substrate scope. The potential applicability of designed methodol. was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug mols. by a one-pot strategy. This study involved multiple reactions and reactants, such as 2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5Electric Literature of C13H11BrN2O).
2-Amino-N-(2-bromophenyl)benzamide (cas: 34489-85-5) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Electric Literature of C13H11BrN2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics