Davis, H. Lorne published the artcile2,3-Disubstituted 1,8-naphthyridines as potential diuretic agents. 3. 4- and 7-Phenyl derivatives, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is European Journal of Medicinal Chemistry (1985), 20(4), 381-3, database is CAplus.
Naphthyridines I [R = Ph, OH, NH2; R1 = cyano, (un)substituted CONH2, CO2Me; R2, R3 = H, Ph] were prepared Thus, 2-amino-3-benzoylpyridine (II) was cyclized with NCCH2CONH2 to give I (R = OH, R1 = cyano, R2 = Ph, R3 = H) (III). Cyclocondensation of II and CH2(CN)2 gave I (R = NH2; R1 = cyano, R2 = Ph, R3 = H), which was hydrolyzed to I (R1 = CONH2) (IV). III and IV were as potent diuretics as triamterene, but I (R3 = Ph) were inactive.
European Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Recommanded Product: 2-Cyano-N-ethylacetamide.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics