Moschos, Marilita M. published the artcileThe role of historic deacetylase inhibitors in uveal melanoma: current evidence, Recommanded Product: 4-(tert-Butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide, the publication is Anticancer Research (2018), 38(7), 3817-3824, database is CAplus and MEDLINE.
A review. Uveal melanoma is the most common intraocular malignancy in adults, representing approx. 3% of all melanoma cases. Despite progress in chemotherapy, radiation and surgical treatment options, the prognosis and survival rates remain poor. Acetylation of historic proteins causes transcription of genes involved in cell growth, DNA replication and progression of cell cycle. Overexpression of histone deacetylases occurs in a wide spectrum of malignancies. Histone deacetylase inhibitors block the action of histone deaceiylases, leading to inhibition of tumor cell proliferation. This article reviewed the potential therapeutic efects of histone deacetylase inhibitors on uveal melanoma. MEDLINE database was used under the key words/phrases: histone deacetylase, inhibitors, uveal melanoma and targeted therapies for uveal melanoma. A total of 47, English articles, not only referring to uveal melanoma, published up to Feb. 2018 were used. Valproic acid, trichostatin A, tenovin-6, depsipeptide, panobinostat (LBH-589), vorinostat (suberanilohydroxamic acid) entinostat (MS-275), quisinostat, NaB, JSL-I, MC/568 and MC1575 are histone deacetylase inhibitors that have demonstrated promising amitumor effects against uveal melanoma. Histone deacetylase inhibitors represent a promising therapeutic approach for the treannent of weal melanoma.
Anticancer Research published new progress about 1011557-82-6. 1011557-82-6 belongs to amides-buliding-blocks, auxiliary class Epigenetics,Sirtuin, name is 4-(tert-Butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide, and the molecular formula is C25H34N4O2S, Recommanded Product: 4-(tert-Butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide.
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