Bedalov, A. published the artcileBiology, chemistry, and pharmacology of Sirtuins, Recommanded Product: 4-(tert-Butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide, the publication is Methods in Enzymology (2016), 183-211, database is CAplus and MEDLINE.
A review. Sirtuins are a family of protein deacylases related by amino acid sequence and cellular function to the yeast Saccharomyces cerevisiae protein Sir2 (Silent Information Regulator-2), the first of this class of enzymes to be identified and studied in detail. Based on its initially discovered activity, Sir2 was classified as a histone deacetylase that removes acetyl groups from histones H3 and H4. The acetylation/deacetylation of these particular substrates leads to changes in transcriptional silencing at specific loci in the yeast genome, hence its name. Sirtuins, however, have been shown to regulate a wide variety of cellular processes beyond transcriptional repression in varied subcellular compartments and in different cell types. Mechanistically distinct from Zn2+-dependent deacylases, sirtuins use NAD as a cofactor in the removal of acetyl and other acyl groups linking metabolic status and posttranslational modification. Sirtuins’ unique position has made them attractive targets for small-mol. drug development. In this chapter, we describe the biol. roles, therapeutic areas in which sirtuins may play a role and development of small-mol. inhibitors of sirtuins employing phenotypic screening technologies ranging from assays in yeast, as well as biochem. screens to yield lead drug development candidates targeting a broad spectrum of human diseases.
Methods in Enzymology published new progress about 1011557-82-6. 1011557-82-6 belongs to amides-buliding-blocks, auxiliary class Epigenetics,Sirtuin, name is 4-(tert-Butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide, and the molecular formula is C25H34N4O2S, Recommanded Product: 4-(tert-Butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide.
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