Hintermann, Samuel published the artcileIdentification of a series of highly potent activators of the Nurr1 signaling pathway, Application In Synthesis of 100377-32-0, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(1), 193-196, database is CAplus and MEDLINE.
The nuclear receptor Nurr1 (NR4A2) is critically involved in the development and maintenance of midbrain dopaminergic neurons and is believed to function independently of endogenous activation. The hit identification and SAR studies leading to isoxazolo-pyridinone 7e (I), a highly potent, brain penetrable activator of the Nurr1 signaling pathway, are described.
Bioorganic & Medicinal Chemistry Letters published new progress about 100377-32-0. 100377-32-0 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N-Methoxy-N-methylisonicotinamide, and the molecular formula is C8H10N2O2, Application In Synthesis of 100377-32-0.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics