Related Products of 89979-12-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89979-12-4, name is 5-Chloro-2-(methylsulfonamido)benzoic acid belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Compound 63Starting material intermediate 60 (200 mg) was dissolved in 10 ml of dioxane, to the solution was added concentrated HC1 (1 ml). The reaction was completed in 30mins, solvent was evaporated and the residue was used in the next step. 2- methanesulfonamido-5-chlorobenzoic acid (20 mg, 0.08 mmol), HATU (38 mg, 0.1 mmol) were dissolved in anhydrous DMF (2 ml). After activation for 1 hour, to the above solution was added previous step crude product (20 mg, 0.05 mmol) and triethylamine (40 mu). The reaction was stirred under nitrogen for lh. Solvents were removed by rotary evaporation. The residue was purified with preparatory HPLC to provide compound 63. (Yield 9 mg, 26 %).1H-NMR (CD3OD, 400 MHz): delta 8.78 (s, 1H), 7.65 (d, J= 7.2 Hz, 1H), 7.25 (d, J= 7.2 Hz, 1H), 7.18 (s, 1H), 6.68 (s, 1H), 6.1 1 (s, 1H), 4.46 (s, 2H), 3.83 (s, 5H), 3.81 (s, 3H), 3.04-2.94 (m, 3H), 2.91-2.80 (m, 3H), 2.57-2.48 (m, 3H), 2.22-2.16 (m, 2H), 1.76-1.74 (m, 2H), 1.51 (s, 2H). LCMS m/z [M+H]+ C26H31C1N604S requires: 559.18. Found 559.24HPLC Tr (min), purity %: 2.74, 98%
The synthetic route of 5-Chloro-2-(methylsulfonamido)benzoic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GILEAD SCIENCES, INC.; BABAOGLU, Kerim; BOOJAMRA, Constantine, G.; EISENBERG, Eugene, J.; HUI, Hon Chung; MACKMAN, Richard, L.; PARRISH, Jay, P.; SANGI, Michael; SAUNDERS, Oliver, L.; SIEGEL, Dustin; SPERANDIO, David; YANG, Hai; WO2011/163518; (2011); A1;,
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