Abdellattif, Magda H. published the artcileNovel 2-hydroselenonicotinonitriles and selenopheno[2, 3-b]pyridines: efficient synthesis, molecular docking-DFT modeling, and antimicrobial assessment, Application of 2-Chloroacetamide, the publication is Frontiers in Chemistry (Lausanne, Switzerland) (2021), 672503, database is CAplus and MEDLINE.
Selenium containing heterocyclic compounds gained great interest as bioactive mols. as of late. This report explores the design, synthesis, characterization, and antimicrobial screening of new pyridine derivatives endowed with selenium moieties. A one-pot multicomponent system with a solvent-free, microwave irradiation environment was employed to afford this series. The spectroscopic techniques were exploited to verify the structures of the synthesized derivatives Addnl., the agar diffusion method was employed to determine the antimicrobial activity of all the desired compounds Of all the synthesized mols., few compounds exhibited well to remarkable antibacterial and antifungal activities. Moreover, derivative (E)-4,6-dimethyl-2-selenoxo-5-((3,4,5-trimethoxyphenyl)diazenyl)-1,2-dihydropyridine-3-carbonitrile demonstrated the most potent antibacterial and antifungal performance. The results were also supported by mol. docking studies, utilizing the MOE (mol. operating environment) which revealed the best binding mode with the highest energy interaction within the binding pocket. Lastly, theor. DFT calculations were carried out in a gas phase at B3LYP 6-311G (d,p) basis set to predict the mol. geometries and chem. reactivity descriptors. DFT results have been used to illustrate that mol. docking findings and biol. activity assessments.
Frontiers in Chemistry (Lausanne, Switzerland) published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application of 2-Chloroacetamide.
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https://en.wikipedia.org/wiki/Amide,
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