Altomare, C. published the artcileLipophilicity measurements of benzenesulfonamide inhibitors of carbonic anhydrase by reversed-phase HPLC, Computed Properties of 35203-88-4, the main research area is lipophilicity benzenesulfonamide HPLC; carbonic anhydrase inhibitor benzenesulfonamide QSAR.
The lipophilicity of 33 meta and para substituted benzenesulfonamides was studied by reversed-phase HPLC using MeOH-H2O or MeCO-H2O as the mobile phases and μ Bondapak C18 as the stationary phase. A linear relation between the capacity factor (log k’) and the volume fraction of the organic modifier (θ) was established for each solute. The extrapolation of the retention to φ = 0 (0% of organic modifier) 0% organic modifier) permitted the elimination of any selective and specific effects of organic modifier, to calculate log kw and finally to derive τw for each substituent. The Hansch’s π hydrophobic parameter was linearly correlated to τw (r = 0.953), but no improvement in the correlation equation was observed when τw values obtained by adding silanol masking amines to the mobile phase were used. By introducing an indicator variable which takes into account the possibility of the substituent to make hydrogen bonding, a slight but significant improvement was instead observed The replacement of π with τw in the regression equation obtained in a recent QSAR study on carbonic anhydrase inhibition by benzenesulfonamide gives rise to a correlation equation with comparable statistical significance.
International Journal of Pharmaceutics published new progress about Lipophilicity. 35203-88-4 belongs to class amides-buliding-blocks, name is 3-Acetylbenzenesulfonamide, and the molecular formula is C8H9NO3S, Computed Properties of 35203-88-4.
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