Fujikura, Takashi published the artcileStudies on benzenesulfonamide derivatives with α- and β-adrenergic antagonistic and antihypertensive activities, Computed Properties of 35203-88-4, the main research area is benzenesulfonamide sympatholytic antihypertensive preparation; aminoethylbenzenesulfonamide phenylmethylpropyl; phenoxyethylaminoethylbenzenesulfonamide; structure activity benzenesulfonamide aminohydroxyethyl.
New α- and β-adrenergic blockers, benzenesulfonamide derivatives I (R = H, halo, MeO, Me, Pr, MeS, MeSO2; R1 = H, MeO) and II (R2 = Me, MeO, OH; R3 = H, OH, MeO, EtO) were prepared from acetylbenzenesulfonamides. All the target compounds have two asym. centers and therefore consist of two diastereomers. I (R = 2-Me, R1 = 2-MeO) (III) and II (R2 = Me, R3 = 2-MeO) (IV) showed potent α- and β-blocking activities and they were each separated into two diastereomers (III-A and III-B, and IV-A and IV-B) and one isomer had mainly β-blocking activity and the other isomer had mainly α-blocking activity. In addition, several compounds showing relatively strong α- and β-blocking activities were also examined for antihypertensive activity and III and IV were more potent than labetalol. Structure-activity relationships were discussed.
Chemical & Pharmaceutical Bulletin published new progress about Antihypertensives. 35203-88-4 belongs to class amides-buliding-blocks, name is 3-Acetylbenzenesulfonamide, and the molecular formula is C8H9NO3S, Computed Properties of 35203-88-4.
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Amide – Wikipedia,
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