Zaorska, Ewelina published the artcileEvaluation of thioamides, thiolactams and thioureas as hydrogen sulfide (H2S) donors for lowering blood pressure, Safety of N-Methylformamide, the main research area is thioamide thiolactam thiourea derivative preparation H2S donor blood pressure; Cardiovascular; Hydrogen sulfide; Thioamides; Thiolactams; Thiourea.
Hydrogen sulfide (H2S) is a biol. important gaseous mol. that exhibits promising protective effects against a variety of pathol. processes. For example, it was recognized as a blood pressure lowering agent. Aligned with the need for easily modifiable platforms for the H2S supply, we report here the preparation and the H2S release kinetics from a series of structurally diversified thioamides, thiolactams and thioureas. Three different thionation methods based on the usage of a phosphorus pentasulfide and Lawesson reagent were applied to prepare the target thioamides and thiolactams. Furthermore, obtained H2S donors were evaluated both in in vivo and in vitro studies. The kinetic parameters of the liberating H2S was determined and compared with NaHS and GYY4137 using two different detection technics i.e.; fluorescence labeling 7-azido-4-methyl-2H-chromen-2-one and 5,5′-dithiobis (2-nitrobenzoic acid), sulfhydryl probe, also known as the Ellman’s reagent. We have proved that the amount of releasing H2S from these compounds is controllable through structural modifications. Finally, the present study shows a hypotensive response to an i.v. administration of the developed donors in the anesthetized rats.
Bioorganic Chemistry published new progress about Antihypertensives. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics