Li, Hu published the artcileN-formyl-stabilizing quasi-catalytic species afford rapid and selective solvent-free amination of biomass-derived feedstocks, Product Details of C2H5NO, the main research area is carbonyl compound formamide formic acid microwave irradiation reductive amination; amine green preparation.
A protocol was developed that showed in-situ formed N-formyl quasi-catalytic species afforded highly selective synthesis of formamides or amines with controllable levels from a variety of aldehyde- and ketone-derived platform chem. substrates under solvent-free conditions. Up to 99% yields of mono-substituted formamides were obtained in 3 min. The C-N bond formation and N-formyl species were prevalent in the cascade reaction sequence. Kinetic and isotope labeling experiments explicitly demonstrated that the C-N bond was activated for subsequent hydrogenation, in which formic acid acted as acid catalyst, hydrogen donor and as N-formyl species source that stabilized amine intermediates elucidated with d. functional theory. The protocol provided access to imides from aldehydes, ketones, carboxylic acids and mixed-substrates, requires no special catalysts, solvents or techniques and provided new avenues for amination chem.
Nature Communications published new progress about Amination kinetics. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics