Comins, Daniel L. published the artcileSynthesis of MAPA Reagents and 2-Alkyl(aryl)aminopyridines from 2-Bromopyridine Using the Goldberg Reaction, Application In Synthesis of 123-39-7, the main research area is aminopyridine preparation; bromopyridine amide copper catalyst Goldberg reaction; 1,10-phenanthroline; 2-alkyl(aryl)aminopyridines; 2-methylaminopyridine amides; Goldberg reaction; N-methyl-N-(2-pyridyl)formamide; copper-catalyzed reactions; cross-coupling reactions.
A short and economical synthesis of various 2-methylaminopyidine amides (MAPA) from 2-bromopyridine was developed using the catalytic Goldberg reaction. The effective catalyst was formed in-situ by the reaction of CuI and 1,10-phenanthroline in a 1/1 ratio with a final loading of 0.5-3 mol%. The process afforded high yields and accommodated multigram-scale reactions. A modification of this method provided a new preparation of 2-N-substituted aminopyridines from various secondary N-alkyl(aryl)formamides and 2-bromopyridine. The intermediate aminopyridine formamide was cleaved in-situ through methanolysis or hydrolysis to give 2-alkyl(aryl)aminopyridines in high yields.
Molecules published new progress about Amidation catalysts. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics